Successful Treatment of Confluent and Reticulated Papillomatosis with Minocycline Topical 4% Foam

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Hanna Lateef
Ali Kraish
Farooq Lateef


confluent, reticulated, dermatosis, minocycline, topical


Confluent and reticulated papillomatosis of Gougerot and Carteaud (CRP) is a rare dermatosis with many proposed etiologies. Patients typically present with hyperpigmented papules on areas such as their back, chest, abdomen, and axilla which coalesce centrally and form reticular patterns peripherally. CRP is typically recalcitrant to therapy, making it difficult to treat. We report a case of a middle-aged Black woman with a rash on the center of her chest, extending beneath her inframammary folds. The patient was diagnosed with CRP clinically. Due to her concerns regarding oral antibiotics, she was placed on minocycline topical 4% foam for one month. Concluding her therapy, we observed a complete resolution of plaques with residual hyperpigmentation. To date, this is the first report in the literature on the usage of topical minocycline for the treatment of CRP.


1. Gougerot H, Carteaud A. Papillomatose pigmentée innominée. Case pour diagnostic. Bulletin de la Société Françiase de Dermatologie et de Syphiligraphie. 1927; 34: 712-719.

2. Gougerot H, Carteaud A. Neue formen der papillomatose. Archiv für Dermatologie und Syphilis. 1932; 165: 232-267.

3. Wise F, Sachs W. Cutaneous papillomatose: papillomatose confluente et réticulée. Arch Dermatol Syphilol. 1937; 36: 475-485.

4. Wise F. Confluent and reticulated papillomatosis (Gougerot-Carteaud). Arch Dermatol Syphilol. 1937; 35: 550.

5. Schwartz RA. Confluent and Reticulated Papillomatosis. MedScape. Published May 18, 2021. Accessed August 8, 2021.

6. Meischer VG. Erythrokeratodermia papularis et reticularis. Dermatologica. 1954; 108(4-6): 303-309.

7. Thomsen K. Confluent and Reticutared Papillomatosis (Gougerot-Carteaud). Acta Derm Venereol Suppl (Stockh). 1979; 59: 185-187.

8. Kumar AS, Pandhi RK. Syndrome of Carteaud and Gougerot - case report. Confluent and reticulate papillomatosis. Mykosen 1984; 27: 313-315.

9. Scheinfeld, N. Confluent and reticulated papillomatosis: a review of the literature. Am J Clin Dermatol. 2006; 7(5): 305-313.

10. Davis MDP, Weenig RH, Camilleri MJ. Confluent and reticulated papillomatosis (Gougerot-Carteaud syndrome): a minocycline-responsive dermatosis without evidence for yeast in pathogenesis. A study of 39 patients and a proposal of diagnostic criteria. Br J Dermatol. 2006; 154(2): 287–93.

11. Lim JHL, Tet LH, Chong W. Confluent and reticulated papillomatosis: diagnostic and treatment challenges. Clin Cosmet Investig Dermatol. 2016; 9: 217–23.

12. Angeli-Besson C, Koeppel MC, Acquet PJ, Andrac L, Sayag J. Confluent and reticulated papillomatosis (Gougerot-Carteaud) treated with tetracyclines. Int J Dermatol. 1995; 34(8): 567-569.

13. Gruber E, Zamolo G, Saftic M, Perhada V, Kastelan M. Treatment of confluent and reticulated papillomatosis with azithromycin. Clin Exp Dermatol. 1998; 23(4): 191.

14. Jang HS, Oh CK, CHat JH, Cho SH, Kwon KS. Six cases of confluent and reticulated papillomatosis alleviated by various antibiotics. J Am Acad Dermatol. 2001; 44(4): 652-655.

15. Kim BS, Lim HJ, Kim HY, Lee WJ, Lee SJ, Kim do W. Case of minocycline-effective confluent and reticulated papillomatosis with unusual location on forehead. J Dermatol. 2009; 36(4): 251-253.

16. Kagi MK, Trueb R, Wuthrich B, Burg G. Confluent and reticulated papillomatosis associated with atopy. Successful treatment with topical urea and tretinoin. Br J Dermatol. 1996; 134(2): 381–382.

17. Bowman PH, Davis LS. Confluent and reticulated papillomatosis: response to tazarotene. J Am Acad Dermatol. 2003; 48(5 suppl): S80–S581.

18. Gulec AT, Seckin D. Confluent and reticulated papillomatosis: treatment with topical calcipotriol. Br J Dermatol. 1999; 141(6): 1150–1151.

19. Kurkeuoglu N, Celebi CR. Confluent and reticulated papillomatosis: response to topical calcipotriol. Dermatol. 1995; 191(4): 341–342.

20. Tirado-Sánchez A, Ponce-Olivera RM. Tacrolimus in confluent and reticulated papillomatosis of Gougerot Carteaud. Int J Dermatol. 2013; 52(4): 513–514.

21. Nordby CA, Mitchell AJ. Confluent and Reticulated papillomatosis responsive to selenium sulfide. Int J Dermatol. 1986; 25(3): 194-199.

22. Onge ES, Mobley WC. Minocycline Topical Foam: A New Drug for the Treatment of Acne. Ann Pharmacother. 2021 Jan; 55(1): 105-110.

23. Eady EA, Cove JH. Topical antibiotic therapy: current status and future prospects. Drugs Exp Clin Res. 1990; 16(8): 423-33.