Herpes Zoster Post-COVID-19 Vaccination in Young Adults (Under 35) Case Series

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Sophie Guenin
Emily Elbogen
Mindy Kresch
Mark Lebwohl


herpes zoster, varicella zoster reactivation, virology, general dermatology, medical dermatology, mRNA vaccine, COVID-19


An increasing number of reports have indicated correlation between COVID-19 vaccination and herpes zoster. While these outbreaks may be largely coincidental, the correlation warrants further investigation. Herein, we present 4 cases of herpes zoster in young healthy adults with no known risk factors for varicella virus reactivation. To date, most zoster outbreaks have been in patients above 60 years old. Thus, we believe that these cases point to a need for increased research on the topic. 


1. Lee, C., Cotter, D., Basa, J., & Greenberg, H. L. (2021). Post COVID‐19 Vaccine Related Shingles Cases seen at the Las Vegas Dermatology Clinic and sent to us via Social Media. Journal of Cosmetic Dermatology.

2. Channa, L., Torre, K., & Rothe, M. (2021). Herpes zoster reactivation after mRNA-1273 (Moderna) SARS-CoV-2 vaccination. JAAD Case Reports, 15, 60-61.

3. Eid, E., Abdullah, L., Kurban, M., & Abbas, O. (2021). Herpes zoster emergence following mRNA COVID‐19 vaccine. Journal of Medical Virology.

4. Bostan, E., & Yalici-Armagan, B. (2021). Herpes zoster following inactivated COVID-19 vaccine: a coexistence or coincidence?. Journal of Cosmetic Dermatology.

5. Lladó, I., Fernández-Bernáldez, A., & Rodríguez-Jiménez, P. (2021). Varicella zoster virus reactivation and mRNA vaccines as a trigger. JAAD Case Reports, 15, 62-63.

6. Gershon, A. A., Breuer, J., Cohen, J. I., Cohrs, R. J., Gershon, M. D., Gilden, D., ... & Yamanishi, K. (2015). Varicella zoster virus infection. Nature reviews Disease primers, 1(1), 1-18.

7. Katsikas Triantafyllidis, K., Giannos, P., Mian, I. T., Kyrtsonis, G., & Kechagias, K. S. (2021). Varicella Zoster Virus Reactivation Following COVID-19 Vaccination: A Systematic Review of Case Reports. Vaccines, 9(9), 1013.

8. Anderson, E. J., Rouphael, N. G., Widge, A. T., Jackson, L. A., Roberts, P. C., Makhene, M., ... & Beigel, J. H. (2020). Safety and immunogenicity of SARS-CoV-2 mRNA-1273 vaccine in older adults. New England Journal of Medicine, 383(25), 2427-2438.

9. Sahin, U., Muik, A., Derhovanessian, E., Vogler, I., Kranz, L. M., Vormehr, M., ... & Türeci, Ö. (2020). COVID-19 vaccine BNT162b1 elicits human antibody and TH 1 T cell responses. Nature, 586(7830), 594-599.

10. Walter, R., Hartmann, K., Fleisch, F., Reinhart, W. H., & Kuhn, M. (1999). Reactivation of herpesvirus infections after vaccinations?. The Lancet, 353(9155), 810.

11. Mulligan, M. J., Lyke, K. E., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., ... & Jansen, K. U. (2020). Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults. Nature, 586(7830), 589-593.

12. Kamphuis, E., Junt, T., Waibler, Z., Forster, R., & Kalinke, U. (2006). Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood, 108(10), 3253-3261.

13. Laing, K. J., Ouwendijk, W. J., Koelle, D. M., & Verjans, G. M. (2018). Immunobiology of varicella-zoster virus infection. The Journal of infectious diseases, 218(suppl_2), S68-S74.

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