Common Adverse Drug-Drug Interactions in Dermatology: Oral Therapies

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Joanna Dong
Lauren Bonomo
Mark Lebwohl


drug-drug interactions, oral therapies, methotrexate, acitretin, bexarotene, macrolides, cyclosporine, epinephrine, isotretinoin, spirinolactone, allopurinol, oral contraceptives


Drug-drug interactions between systemic oral therapies in dermatology can result in preventable iatrogenic causes of patient morbidity and mortality. Most of these interactions are due to cytochrome P450 or renal excretion interactions. We review here a number of drugs and drug-drug interactions seen in general dermatology, including methotrexate, bexarotene, macrolides, cyclosporine, epinephrine, isotretinoin, spirinolactone, allopurinol, and oral contraceptives.


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