Nab-paclitaxel/Gemcitabine Induced Acquired Ichthyosis

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Adriana T Lopez
Joel Shugar
Mark Lebwohl


acquired ichthyosis, ichthyoses, gemcitabine, nab-paclitaxel


The ichthyoses are a diverse group of cutaneous disorders characterized by abnormalities in cornification. The majority of ichthyoses are inherited with childhood presentation and new onset ichthyosis in adulthood warrants further medical evaluation. Though most well recognized for its association with Hodgkin’s disease, acquired ichthyosis (AI) has been linked to a number of inflammatory, autoimmune, and endocrine processes. However, drug induced AI is exceedingly rare and remains a poorly understood entity. Here we report the case of man with who developed AI while receiving nab-paclitaxel plus gemcitabine for treatment of pancreatic adenocarcinoma and review the literature.


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