Impact of Depression on Health-Related Quality of Life among Skin Cancer Survivors

Main Article Content

Kaustuv Bhattacharya
Namita Joshi
Ruchit Shah
Vinayak K. Nahar



Introduction: Skin cancers are one of the most common cancers in the United States (US).  Studies have reported depression to be a common comorbid condition among individuals with skin cancer. This study aimed to evaluate the relationship of depression with health-related quality of life (HRQOL) among individuals with a skin cancer diagnosis.

Methods: A cross-sectional study design using the 2017 Behavioral Risk Factor Surveillance System (BRFSS) data, a nationally representative sample of non-institutionalized US adults, was utilized for the study. Multivariable logistic regression was used to assess the relationship between depression and the HRQOL domains (general health status, physical health, mental health, and activity limitations due to poor physical or mental health) among survivors of skin cancer.

Results: Comorbid depression was identified in 20% of skin cancer survivors. After adjusting for covariates, skin cancer survivors with depression had higher odds of having poor general health status (Odds Ratio [OR] = 1.67, 95% Confidence Interval [CI] 1.41-1.98) as compared to skin cancer survivors without depression. Skin cancer survivors with depression also had greater odds of having poor physical HRQOL (OR = 1.82, 95% CI 1.53-2.15), poor mental HRQOL (OR = 6.38, 95% CI 5.26-7.74), and activity limitations (OR = 2.42, 95% CI 2.03-2.89) as compared to those without depression.

Conclusion: This study highlights the significant negative impact of comorbid depression on HRQOL in a nationally representative sample of skin cancer survivors, and serves as evidence for the need for more active surveillance and management of depression in this population.



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