Recurrent Keratoacanthoma

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Isabella Kest
Kaylee Fisher
Nahla Shihab
Mark Lebwohl


recurrent keratoacanthoma, methotrexate, squamous cell carcinoma


Keratoacanthoma (KA) is a cutaneous squamoproliferative tumor with multiple etiologies suggested. KA can have a benign course, resolving spontaneously, but because it can rarely metastasize, some consider it to be a form of squamous cell carcinoma (SCC). We report a 65-year-old Caucasian male diagnosed with KA in the conch of the left ear, which initially resolved with intralesional methotrexate, but eventually recurred.


1. Brewer JD. Keratoacanthoma: Management and prognosis. [Updated 2019 Mar 11]. In: UpToDate [Internet]. Available from: (accessed 21 July 2019).

2. Zito PM, Scharf R. Keratoacanthoma. Treasure Island (FL): StatPearls Publishing, 2018.

3. Kwiek B, Schwartz RA. Keratoacanthoma (KA): An update and review. J Am Acad Dermatol. 2016 Jun;74(6):1220-33. Epub 2016 Feb 4.

4. Patel NP, Cervino AL. Treatment of keratoacanthoma: Is intralesional methotrexate an option?. Can J Plast Surg. 2011;19(2):e15–e18.

5. Scalvenzi M, Patrì A, Costa C, et al. Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience. Dermatol Ther (Heidelb). 2019;9(2):369–372. Published 2019 Feb 21. doi:10.1007/s13555-019-0286-1

6. Cuesta-Romero C, de Grado-Peña J. Intralesional Methotrexate in Solitary Keratoacanthoma. Arch Dermatol.1998;134(4):513–514. doi:10.1016/j.jaad.2006.12.017

7. Valle VD, Milani M. Efficacy and Safety of Intralesional Methotrexate in the Treatment of a Large Keratoacanthoma of the Dorsal Hand in a 99-Year-Old Woman. Case Rep Dermatol. 2018;10:247–250. doi:10.1159/000494322

8. Goldberg LH, Silapunt S, Beyrau KK, Peterson S, Friedman PM, Alam M. Keratoacanthoma as a postoperative complication of skin cancer excision. A Journal of the American Academy of Dermatology. 2004;50(5):753-758. doi:10.1016/j.jaad.2003.11.065

9. Hadley JC, Tristani-Firouzi P, Florell SF, Bowen GM, Hadley ML. Case Series of Multiple Recurrent Reactive Keratoacanthomas Developing at Surgical Margins. Dermatologic Surgery. 2009;35(12):2019-2024. doi:10.1111/j.1524-4725.2009.01327.x

10. Hunter-Ellul L, Reddy S, Dacso M, Robare-Sout S, Wilkerson M. Rapidly recurring keratoacanthoma. Cutis. 2015 Apr;95(4)E7-8.

11. Garcia-Zuazaga J, Ke M, Lee P. Giant keratoacanthoma of the upper extremity treated with mohs micrographic surgery: a case report and review of current treatment modalities. J Clin Aesthet Dermatol. 2009;2(8):22–25.

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