Percutaneous Penetration: Reliability of Mathematical Models

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Anuk Burli
Rebecca Law
Howard Maibach


Percutaneous Penetration, Pharmacology, Sunscreen, Pesticides, Occupational, Steroids


1. Burli A, Law RM, Rodriguez J, Maibach HI, (2020). Organic compounds percutaneous penetration in vivo in man: Relationship to mathematical predictive model. Regul Toxicol Pharmacol.112:104614. doi: 10.1016/j.yrtph.2020.104614.

2. Burli A, Law RM, Maibach HI. Ability of mathematical models to predict human in vivo percutaneous penetration of steroids. Regul Toxicol Pharmacol. 2021 Nov;126:105041. doi: 10.1016/j.yrtph.2021.105041. Epub 2021 Sep 6

3. Cheruvu HS, Liu X, Grice JE, Roberts MS., (2020). Modeling percutaneous absorption for successful drug discovery and development. Expert Opin Drug Discov. 15(10):1181-1198. doi: 10.1080/17460441.2020.1781085.

4. Matta MK, Florian J, Zusterzeel R, et al. Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial. JAMA. 2020;323(3):256–267. doi:10.1001/jama.2019.20747

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